Mesothelioma and Work Exposure Mesothelioma is more frequent in people who work with asbestos. Construction workers, firefighters and military veterans are at a higher risk. The lung's lining (pleural mesothelioma), or the abdomen, is the most common mesothelioma's primary site. In rare cases, it can affect the heart and testicles. https://vimeo.com/705023383