Gastrointestinal (GI): NSAIDs that block COX-one action have correlations with GI problems mainly because of the inhibition with the synthesis of gastroprotective brokers including PGE2 as well as other prostaglandins. This inhibition contributes to decreased mucin generation by gastric epithelial cells, much less bicarbonate secretion, and fewer epithelial cell turnover, https://williamz702lqu1.vidublog.com/profile