Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals in the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions, which m... https://xiaopinga974tbk2.blog2news.com/profile