Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals with the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions,... https://robertd322uix8.birderswiki.com/user