You will find a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to reduce afferent suffering transmission and create analgesia. Thus, drugs like clonidine that target alpha-2 receptors can influence the transmission of ache. Clonidine is distributed in breast milk; https://vasilievichg035gca4.blogunteer.com/profile